Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity

Brain Plasticity and Neurorestoration by Environmental Enrichment

Plasticity of Dentate Granule Cell Mossy Fiber Synapses: A Putative Mechanism of Limbic Epileptogenesis

The epilepsies constitute the third most common serious neurological disorder. Among the more than 40 different types of epilepsy, limbic epilepsy is the single most common and devastating form. Antiseizure drugs provide symptomatic relief, in that they suppress seizures, yet limbic seizures persist in 30–40% of patients and unwanted effects of drugs are common. No disease modifying therapies a...

synaptic neuronal plasticity

context the current study aimed to review research articles concerning cortical representational plasticity following the manipulations of inputs. evidence acquisition this review article compromised previous studies in pubmed, google scholar and scientific information databases according to the keywords since 1988. results ca1 neurons depolarization paired with ca3 presynaptic input result in ...

P7: The Role of Aquaporins in Synaptic Plasticity and Epilepsy

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MSK1 regulates environmental enrichment-induced hippocampal plasticity and cognitive enhancement.

Environmental enrichment (EE) has marked beneficial effects on cognitive capacity. Given the possibility that this form of neuronal plasticity could function via the actuation of the same cellular signaling pathways that underlie learning/memory formation, we examined whether the MAPK cascade effector, mitogen/stress-activated kinase 1 (MSK1), could play a role in this process. MSK1 functions a...